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KMID : 0545120170270111994
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Journal of Microbiology and Biotechnology
2017 Volume.27 No. 11 p.1994 ~ p.1998
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Madurahydroxylactone, an Inhibitor of Staphylococcus aureus FtsZ from Nonomuraea sp. AN100570
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Kim Bo-Min
Choi Ha-Young
Kim Geon-Woo
Zheng Chang-Ji
Kim Young-Ho
Kim Won-Gon
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Abstract
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FtsZ, a bacterial cell-division protein, is an attractive antibacterial target. In the screening for an inhibitor of Staphylococcus aureus FtsZ, madurahydroxylactone (1) and its related derivatives 2-5 were isolated from Nonomuraea sp. AN100570. Compound 1 inhibited S. aureus FtsZ with an IC50 of 53.4 μM and showed potent antibacterial activity against S. aureus and MRSA with an MIC of 1 μg/ml, whereas 2-5 were weak or inactive. Importantly, 1 induced cell elongation in the cell division phenotype assay, whereas 2-5 did not. It indicates that 1 exhibits its potent antibacterial activity via inhibition of FtsZ, and the hydroxyl group and hydroxylactone ring of 1 are critical for the activity. Thus, madurahydroxylactone is a new type of inhibitor of FtsZ.
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KEYWORD
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Madurahydroxylactone, FtsZ, inhibitor, Nonomuraea, antibacterial
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